WELCOME TO THE TRANSFORM TOX TESTING CHALLENGE:
INNOVATING FOR METABOLISM
Out of thousands of chemicals in use today, very few have been fully evaluated for potential health risks.
The U.S. Environmental Protection Agency (EPA), the National Institutes of Health’s (NIH) National Center for Advancing Translational Sciences (NCATS), and the National Toxicology Program (NTP), headquartered at the National Institute of Environmental Health Sciences (NIEHS), are pleased to announce the launch of the Transform Tox Testing Challenge.
Scientists from EPA, NTP and NCATS have used high-throughput screening (HTS) assays to evaluate the potential health effects of thousands of chemicals. The Transform Tox Testing Challenge: Innovating for Metabolism is calling on innovative thinkers to find new ways to incorporate physiological levels of chemical metabolism into HTS assays. Since current HTS assays do not fully incorporate chemical metabolism, they may miss chemicals that are metabolized to a more toxic form. Adding metabolic competence to HTS assays will help researchers more accurately assess chemical effects and better protect human health.
We are looking for innovative technological solutions to retrofit these assays to allow both chemicals and their metabolite products to be evaluated. With your help, we can transform chemical testing methods to make them more relevant to real life and more effective at predicting health effects.
Download a PDF version of this site here.
Do you have a solution that could fill this critical gap in environmental science and technology?
Call for Proposals
SEMI-FINALISTS ANNOUNCED MAY 16, 2016
FOLLOW THE COMPETITION
In the first stage of the Challenge, solvers submitted practical designs for how HTS assays could be retrofitted to include xenobiotic metabolic competence. Ten impressive submissions were selected as semi-finalists, awarded a prize of $10,000 each, and participated in the semi-finalist workshop discussions.
The ToxTest Team is working to finalize materials for the upcoming launch of Stage 2 of the challenge. Stay tuned for more information soon!